3,4-苯并芘標(biāo)準(zhǔn)溶液

產(chǎn)品編號(hào)：Y0255

英文名稱(chēng)：3,4-Benzopyrene solution

CAS號(hào) 50-32-8

5.0μg/mL,基體:甲醇

分子式 C20H12 分子量252.31

基本信息:

敏感性  對(duì)光線(xiàn)敏感

密度  1.0000

溶解性  不溶于水，微溶于乙醇、甲醇，溶于苯、甲苯、二甲苯、氯仿、乙醚、丙酮等。

存貯條件  陰涼干燥通風(fēng)處存儲(chǔ)。

描述

別名  ;3,4-Benzpyrene Benzo[def]chrysene Benzo[a]pyrene

應(yīng)用  A polycyclic aromatic hydrocarbon (PAH), environmental pollutant and carcinogen. Used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.